Innovating Chemistry for a Safer, Sustainable Future
About Us
Tygrus is a Life Science, Research & Development, and Licensing company dedicated to creating safer, more effective chemical alternatives across various industries. Headquartered in Troy, Michigan, with an 18,000 sq. ft. manufacturing facility in Madison Heights, Michigan, Tygrus has developed disruptive platform technology based on Tydronium™—a patented acid designed to replace hazardous disinfectants, toxic preservatives, and harmful chemicals.
Tygrus holds an extensive portfolio of intellectual property, with eight USPTO patents and twenty-five international patents, underscoring its commitment to chemical innovation. Through a global licensing model, Tygrus is targeting key vertical markets, including agriculture, biotech, and personal care.
With ongoing research, strategic partnerships, and a focus on sustainability, Tygrus is poised to make highly significant contributions to global health and environmental wellbeing.
Our Mission
We are committed to advancing global health and sustainability by replacing hazardous chemicals with safer, more sustainable alternatives. Our aim is to transform key industries—including agriculture, personal care, and respiratory therapeutics—through innovative solutions that reduce environmental harm, eliminate toxic preservatives, and provide effective treatments to reduce reliance on antibiotics.
Environmental Sustainability
It is all about Sustainability at Tygrus. Our technology can replace many hazardous chemicals used in agriculture, personal care, and industrial applications with safe, effective alternatives that:
- Reduce waterway and groundwater contamination by potentially reducing toxic runoff from traditional agrochemicals.
- Improve soil health and plant vitality, helping farmers regenerate and preserve farmland for future generations.
- Replace corrosive activators in industrial disinfectant processes (e.g., chlorine dioxide generation) with safer alternatives like Typhall™, reducing material waste and equipment degradation.
- Extend food shelf life with products like Freshful™ and Freshtec™, lowering food waste across the supply chain.
- Eliminate toxic preservatives in personal care products via Tydreau Water™ and Tydracin™, reducing chemical load on the body and the environment.
- Offer safer chemical alternatives that have passed EPA Six-Pack testing, proving to be significantly less corrosive and less toxic than conventional counterparts.
Social Sustainability
Our chemistry is designed not just to protect the environment—but to protect people. All Tygrus chemistry is built with a focus on reducing toxicity to humans, plants, animals, and ecosystems—ensuring safety at every step, from production to application.
- Safer for workers: Tygrus-enabled products reduce the need for handling harsh acids, disinfectants, and preservatives in agriculture, food processing, and cosmetics.
- Better for consumers: Wonderus personal care solutions replace toxic preservatives linked to skin irritation, hormonal disruption, and respiratory issues.
- Improving food safety: Aqueus solutions like Freshful™ meet GRAS (Generally Regarded as Safe) standards, offering safer, cleaner food handling and consumption.
- Supporting global health: Miracus is conducting initial clinical studies on Tydracin™, a broad-spectrum respiratory therapeutic shown effective against AMR pathogens, viruses, and fungi—offering a critical tool for pandemic preparedness and reducing antibiotic overuse.
Scientific Validation
EPA Six-Pack Testing confirms the low toxicity and reduced corrosiveness of Tygrus chemistries.
Phase 1 In-human clinical trials of Tydracin™ show no adverse effects, supporting its safety as a potential respiratory therapeutic.
GRAS determination for Freshful™ in food applications reflects a high standard of product safety and environmental compliance.
Applications
Tygrus is revolutionizing chemical performance with emphasis on innovation, safety, and sustainability.
Agriculture
Growthful™
Enhances soil health resulting in increased crop yields
Cosmetics
Tydreau Water™
Eliminates the need for harmful preservatives in personal care products
Biotech
Tydracin™
Provides an effective, non-antibiotic treatment for respiratory infections
Company Stucture
Tygrus LLC is the parent company that licenses its technology to three wholly owned subsidiaries. These Delaware limited liability companies hold global exclusive, perpetual licensing rights in their respective market sectors.
Agriclulture
Biotech
Personal Care
AgTech
Aqueus LLC
Aqueus is pioneering regenerative agriculture with its flagship product Growthful™, a revolutionary soil amendment designed to improve soil structure, and boost nutrient availability, leading to an increase in crop yields. This sustainable solution leverages Tygrus technology to enhance soil conditions and support the plant’s natural nutrition process. Versatile and effective, Growthful™ can be used across various types of agriculture, including row crops, vegetables, fruits, forage crops, and more.
The Data Doesn’t Lie
Soybeans: 6.3 bushels per acre average increase.
Sugar Beets: 800 lbs. per acre average increase.
Corn: 9.0 bushels per acre average increase.
Lettuce: 5,600 lbs. per acre average increase.
Wheat: 4.0-6.0 bushels per acre average increase.
Biotech
Miracus LLC
Miracus LLC is focused on developing innovative respiratory therapeutics, particularly non-antibiotic solutions for respiratory infections. Its leading product, Tydracin™, is designed to treat infections and chronic conditions with and has demonstrated a strong safety profile with significant efficacy in pre-clinical testing. strong pre-clinical performance. With a leadership team anchored by world-renowned regenerative medicine pioneer Dr. Anthony Atala and supported by global consultancy Verta Life Science, Miracus is positioned at the forefront of next-generation respiratory care.
Flagship Innovation
Tydracin is Miracus’s leading respiratory therapeutic, designed to treat a broad spectrum of infections and chronic respiratory conditions.
Administered via standard nebulizers, Tydracin is a patient-friendly, non-invasive solution showing strong efficacy in pre-clinical models.
In April 2025, Miracus began a Phase II clinical trial in the Dominican Republic, targeting sinusitis, marking a significant milestone in its path toward commercialization.
Strategic Market Opportunity
Respiratory diseases remain a leading global health burden, exacerbated by rising AMR concerns.
The global respiratory therapeutics market is projected to surpass $150 billion by 2030, creating a substantial opportunity for differentiated products like Tydracin.
Miracus aims to launch licensing discussions in 2026, targeting pharmaceutical companies with established respiratory portfolios.
Key Differentiators
Innovative
Chemistry
Tydracin leverages Tygrus’s proprietary technology to address complex infections without contributing to resistance.
Strong Clinical Trajectory
Ongoing trials are designed to validate both efficacy and safety in targeted respiratory indications.
Scalable
Administration
Uses commercially available nebulizers, ensuring low barriers to adoption and wide accessibility
Global
Health Impact
Addresses a critical unmet need in treating AMR-related respiratory infections, positioning Miracus as a public health enabler
Growth Strategy
The Miracus strategic plan is to close an international joint venture in 2025 and a pharmaceutical license in 2026. This approach supports a capital-efficient path to commercialization and rapid market penetration.
With a world-class team, breakthrough therapeutic chemistry, and a high-growth target market, Miracus LLC is poised to become a leading innovator in inhalation therapy.
Personal Care | Beauty
Wonderus LLC
Wonderus LLC offers innovative, sustainable alternatives to toxic preservatives in the personal care industry. Its products, like Tydreau Water™ and Tydracin™, provide safe, effective, and environmentally friendly solutions for cosmetics and personal care products.
Innovative Solutions
Tydreau Water™
A proprietary formulation based on Tydronium, engineered to replace traditional preservatives in complex product formulations. This innovative approach enhances both the safety and stability of products, eliminating the need for conventional preservatives.
Tydracin™
A safer, effective alternative to hypochlorous acid, offering enhanced stability, odorless and colorless properties, and antioxidant benefits, making it ideal for use in OTC personal care products
Consumer and Formulator Benefits
Healthier
Products
Elimination of toxic preservatives and harsh chemicals
Enhanced
Efficacy
Improved formulation stability and performance
Market
Appeal
Alignment with the growing clean beauty trend
Operational
Efficiency
Simplified formulation, handling, and stabilization processes
Extended
Shelf Life
Reduced need for synthetic preservatives
Growth Strategy
Business Model
Wonderus operates a licensing-based business model, partnering with personal care manufacturers and brands. The company’s solutions offer a compelling value proposition, positioning Wonderus for significant growth and leadership in the personal care industry.
Wonderus LLC is poised to lead the transformation in the personal care and cosmetics industry by providing innovative, safe, and sustainable alternatives to traditional preservatives and hypochlorous acid. With strong market opportunity, cutting-edge solutions, and a scalable business model, Wonderus is well-positioned for long-term success and impact in the clean beauty sector.
Technlogy
Disruptive Chemistry
What is Tydronium?
Tydronium™ is a groundbreaking chemical solution developed by Tygrus that is significantly safer and less corrosive compared to traditional acids.
How does it work?
Through a proprietary manufacturing process, Tydronium stabilizes novel proton structures, enabling high efficacy while reducing the aggressive reactivity commonly seen in traditional acids.
Why is it different?
Unlike conventional acids which rapidly dissociate protons (hydrogen ions), Tydronium dissociates in a controlled, stable manner, making it safer, more manageable, and reducing the risks typically associated with harsh acids.
Scientific Description
Tydronium® is an advanced acid chemistry granted a composition-of-matter patent (US10,446,327) for its uniquely stable acid electrolyte. The United States Patent and Trademark Office (USPTO) recognizes that the process involves the harvesting of protons (H⁺), their controlled condensation and configuration, and the stabilization of the resulting structure. This is made possible through a proprietary, chemically engineered system designed to create the precise conditions necessary for the reaction to take place.
Safety Testing & Regulatory
Safety Testing
Tygrus’ flagship product, Tydronium™, has undergone the EPA “6-Pack” Safety Tests, which assesses the safety profile of chemical substances, particularly for their use in pesticides, industrial chemicals, and antimicrobial products.
Tydronium Safety Highlights
According to the EPA Standardized 6 pack test
- Acute Oral Toxicity: Rated “Least Toxic” (IV)
- Acute Dermal Toxicity: Rated “Least Toxic” (IV)
- Acute Inhalation Toxicity: Rated “Least Toxic” (IV)
- Primary Skin Irritation: Rated “Least Toxic” (IV)
- Skin Sensitization: Rated “Least Toxic” (IV)
- Eye Irritation: Rated “Minimal Toxic” (III)
espite being safer at a 50% dilution, the majority of our formulations are produced at less than 5% concentration making these formulations 10x less toxic than the EPA tests. These results establish Tydronium as a safer alternative to many conventional acids, making it suitable for diverse applications in agriculture, personal care and healthcare.
Regulatory Approvals
GRAS Rating: “GRAS” is an acronym for the phrase Generally Recognized As Safe. Under sections 201(s) and 409 of the Federal Food, Drug, and Cosmetic Act (the Act), any substance that is intentionally added to food is a food additive, that is subject to premarket review and approval by FDA, unless the substance is generally recognized, among qualified experts, as having been adequately shown to be safe under the conditions of its intended use, or unless the use of the substance is otherwise excepted from the definition of a food additive.
Tygrus GRAS Approvals:
- Freshful™ Plus, a novel aqueous preservation technology based on patented chemistry has been determined to be GRAS (Generally Recognized As Safe) through scientific procedures in accordance with 21 CFR Part 170.30(a) and (b ) for use on cut and uncut raw fruits and vegetables.
- TypHall™ Plus, a novel aqueous proton catalyst technology for chlorine dioxide generation and based on patented chemistry has been determined to be GRAS (Generally Recognized As Safe) through scientific procedures in accordance with 21 CFR Part 170.30.
- Tydreau™ Water technology a novel aqueous chemistry that creates a unique environment which replaces hazardous conventional preservatives, has been reviewed by Dicentra, a CRO and regulatory firm is safety, quality and compliance matters. They have concluded that Tydreau™ Water is safe for use in cosmetic and personal care products under the current practices of use and concentration described in the certified PSA safety assessment.
Tygrus Managment
John Coppolino
CEO & Director
Larry Carlson
CTO & Director
Art McWood
VP of Manufacturing & Director
Subsidiary Managment
Mike Skinner
CEO of Aqueus
Mike Depew
Senior Agronomist, Aqueus
Scott Allen
President, Wonderus
Dr. Anthony Atala
Chief Medical Advisor, Miracus
Joseph DeVito, PhD
Medical Advisor, Miracus
Advisors
Dr. Stephen L. Johnson
Senior Regulatory Advisor
Eddy Van Der Paardt
Senior Agricultural Advisor
Dr. Greg Voth
Senior Scientific Advisor
Denise Glasmeyer
IP Attorney
Dan Jenuwine
Chairman of the Board, Tygrus
Kenny Yoffy
Board Member,
Tygrus
Özer Firat
Director & Senior International Advisor
Mike Hinkle
Advisor
News
03/28/2025
Miracus LLC announces Phase II Clinical Trials for the treatment of Acute Sinusitis
Miracus LLC announces the launch of a Phase II clinical trial for the treatment of uncomplicated acute bacterial rhinosinusitis (ABRS) and acute viral rhinosinusitis (AVRS)with the Miracus respiratory therapeutic “Tydracin.”
03/19/2025
Tygrus LLC Launches Wonderus LLC to Revolutionize Personal Care with Its Patented, Stabilized, Hydrogen-Based Chemistry
Tygrus LLC announces the launch of Wonderus LLC, a personal care subsidiary dedicated to redefining the industry with groundbreaking sustainable chemistry solutions.
01/15/2025
Mike D. Skinner Promoted to Chief Executive Officer and Director of Aqueus LLC
Tygrus LLC announced the promotion of Mike D. Skinner to Chief Executive Officer of its food and agricultural subsidiary, Aqueus LLC. Mr. Skinner will also join the subsidiary’s Board of Managers.
Tydracide Testing Shows Greater Than 99.999% Kill Rate on COVID-19 Virus in One Minute
Tygrus LLC announced today that tests conducted by a Center for Disease Control and Prevention (CDC) authorized Bio Safety Level 3 laboratory on its new ingredient, Tydracide, showed that the formulation eliminated the SARS-CoV-2 virus in 1 minute at greater than 5-Log (99.999%) reduction.
05/28/2020
Mayor Says Tygrus Contributes to Oakland County’s Economic Prosperity
The Mayors of Madison Heights and Hazel Park captivated an audience of local business people and community leaders Friday morning with stories of community success.